CLINICOPATHOLOGICAL STUDY ON POORLY DIFFERENTIATED ADENOCARCINOMA OF THE STOMACH-WITH SPECIAL REFERENCE TO THE HISTOLOGIC TYPES

Abstract

In order to clarify the biological properties of poorly differentiated adenocarcinoma of the stomach, a clinicopathological study was conducted for 251 cases by subclassifing into a group having solid-type (51 cases) and the other having non-solid-type (200 cases) tumors.
1) Solid-type tumor was predominant in men, and the average age of patients with non-solid-type tumor was significantly younger.
2) On gross type, Borrmann III and II tumors were common among solid-type cases, whereas type IV and III tumors predominated in the others.
3) There was a significantly higher incidence of venous invasion in the solid-type tumors, with a greater extent of invasion.
4) Metastasis to the lymphnodes was present in 82.0% of the solid-type cases and 79.0% of non-solid-type cases, with no significant difference. However, a significantly (p<0.01) higher incidence of metastasis to the liver was not in solid-type cases (3.0%) than the other (13.7%).
5) Poorly differentiated adenocarcinoma had a poor prognosis. When 5-year survival rate was compared between these subgroups, it was 43.5% for solid-type group and 33.6% for the other, indicating a somewhat favorable prognosis for solid-type tumors.