Abstract
Serum CA19-9, DU-PAN-2, and SPan-1 are useful markers for diagnosing malignant tumors of the pancreas and biliary organs, however, these tumor markers can be positive for benign diseases. Recently a case of cholecystolithiasis with choledocholithiasis showing CA19-9 of more than 10, 000U/ml, DU-PAN-2 of 930U/ml, and SPan-1 of 1, 900U/ml was experienced. Sometimes we see benign cases with positive CA19-9, but rarely encounter cases with positive DU-PAN-2 and/or SPan-1. Here this case as well as a review of the literature is presented.
A 75-year-old woman consulted a nearby practioner because of abdominal pain, jaundice and fever, and was referred to the hospital for close examination. Percutaneous transhepatic cholangiography and drainage of the gallbladder was performed. Tumor markers gradually decreased with an improvement of jaundice. Based on cholecystographic findings, the patient was diagnosed as cholecystolithiasis with choledocholithiasis. Operation was performed and both cholecystolithiasis and choledocholithiasis were confirmed, but no malignancies were found in the gallbladder macroscopically and histologically. After the operation negative-conversion of these tumor markers was noted, and the patient was discharged from the hospital.
