Abstract
Lymphocyte subpopulation in peripheral blood of patients with colorectal cancer were identified by two colar analysis and flow cytometry using monoclonal antibodies, and serum immunosuppressive acidic protein (IAP) was examined before surgical operation. The absolute number of OKT4+2H4+ (suppressor inducer T) cell in patients with colonic cancer were significantly lower than those with rectal cancer. There were significant differences between stage I and III, stage I and IV. The absolute number of OKT4+2H4+ (suppressor T) cells tended to increase as the disease become advanced. There was no significant difference in the absolute number of OKT8+Leu15- (cytotoxic T) and OKT4+2H4- (helper T) cells between colonic and rectal cancer group. Serum IAP in the patients with colonic cancer in stage II, III or IV was significantly higher than that in stage I. Cellular immunity of colorectal cancers have inclined toward minus.
