Case 1: A 60-year-old man was seen at the hospital because of upper abdominal pain. A tumor in the body and tail of the pancreas was suspected on the upper gastrointestinal radiography and CT. Laparotomy was performed on April 19, 1983. A tumor of the size of a fist was observed in the body and tail of the pancreas. Because the tumor directly invaded the stomach and liver, the body and tail of the pancreas was resected together with the lateral segment of the liver, cardiac side of the stomach and spleen. Then, the gastrointestinal tract was reconstructed with the jejunum placed between the esophagus and stomach. On the 31th day after surgery, the patient died of DIC and respiratory failure induced by ruptured suture in esophagojejunostomy. Case 2: A 60-year-old man was suspected to have a cancer of the head of the pancreas on ultrasonography, CT, and Ga scintigraphy. Laparotomy was carried out on October 19, 1988. A tumor of the size of a quail egg was noted in the head of the pancreas. Because the tumor infiltrated into the posterior peritoneum, resection of the tumor was impossible, and gastrojejunostomy and jejunojejunostomy were performed. Both tumors were histologically pancreatic squamous cell cartinoma. In the Japanese literature, 40 cases of pancreatic squamous cell cartinoma and pancreatic adenosquamous cell cartinoma have been reported so far and the prognosis was poor in all cases. Radical resection is often difficult. Multidisciplinary treatment with radical resection, radiotherapy and chemotherapy are recommended like in the treatment of other pancreatic cartinomas.