Abstract
We experienced a case of anal canal cancer with periproctal Paget disease in which conservative treatment was effective.
An 86-year-old man complining of anal bleeding was diagnosed as having an anal canal cancer by elsewhere, and was referred to the hospital. This case is essentially a possible canditate for abdominoperineal rectal resection, but conservative therapy was employed because of his advanced age and association of dementia. The patient was administered doxifluridine 800 mg orally for consecutive 4 weeks, was applied 5-FU ointment locally, and received radiation at a dose of 2Gy a day 20 times, totally 40Gy. Consecuently the anal canal cancer and Paget disease completely disappeared 4 weeks and remission of erosion around the anus was attained 8 weeks after the therapy.
These findings indicate that we can choose more positively a combination of chemotherapy and radiation therapy which permits the anal function to be preserved in the treatment of anal canal cancer.
