1996 Volume 57 Issue 2 Pages 277-280
Each six patients undergoing cardiovascular surgery at the department from November 1993 to June 1994 were assigned to a group received dobutamine alone or another group received dobutamine and amrinone combinedly in an early postoperative period for the purpose of circulatory support. In this study the both groups were compared for hemodynamic response.
There was no significant difference in hemodynamic responses between two groups. Amrinone, known as phosphodiesterase III inhibitor, augment the cardiac function without inclement of O2 consumption of the myocardium.
The combined use of amrinone and dobutamine which have different mechanisms of action each other can be one of choices for treatment immediately after cardiovascular surgery that exerts a synergistic effect to increase the cardiac function and to decrease the dose of catecholamine.
