Abstract
In order to evaluate OK-432, a streptococcal preparation, as an postoperative remedy for the advanced gastric cancer, patients under 70 years of age undergoing curative A or B surgery from 1981-1992 were picked up and retrospectively examined.
Subjects were 67 patients who received immunochemotherapy using OK-432 (OK-432 group) and 74 receiving chemotherapy alone were served as control (control group). Survival rates were compared between 2 groups by clinicopathological factors. OK-432 group showed significantly better outcomes in curative B surgery (p<0.05), and stage IIIa, b (p<0.01). Pathologically, OK-432 group had significantly better survival rates (p<0.05) in the following factors: se of depth of invasion, diffuse type of Lauren's classification, type 2 of gross appearance, and n2 of lymp node metastasis. These results suggest OK-432 can be used effectively for patients with advanced gastric cancer after curative B surgery.
