A 57-year-old woman received morphines orally for her severe chest pain derived from direct invasion of the recurrent parasternal lymph node to the sternum after mastectomy for a breast cancer, because she had already received very intensive prior therapies (i.e. various chemoendocrine therapies and radiotherapy). We tried to control her chest pain with pamidronate because she was not sufficiently relieved from pain with morphines. This therapy brought her remarkable pain relief and she needed morphines only a half of the prior dosage. Thereafter she developed a new lesion except the parasternal lesion that demanded an increase of once decreased morphine dosage. However, she did not complain of chest pain around the parasternal region until her death. In conclusion, it is inferred that pamidronate therapy can be one of good therapeutic options for chest pain derived from direct invasion of the parasternal lymph node recurrence to the sternum.