A CLINICOPATHOLOGICAL STUDY OF COLORECTAL CARCINOMA WITH MUCINOUS COMPONENT

Abstract

Among 562 resected cases of colorectal carcinoma, carcinomas with mucinous compenent (MC) were classified into three groups; mucinous carcinoma (MC_??_50%), 25%<MC<50%, and MC_??_25% according to mucinous area ratio on largest cross-section of the tumor. Those three groups were clinicopathologically compared with differentiated type carcinomas without MC.
The ratio of threegroups were 4.8%, 5.0% and 4.4%. The incidence of lymph node metastasis and peritoneal dissemination in the mucinous carcinomas were higher than those in differentiated type and that of peritoneal dissemination in the group (25%<MC<50% was higher similarly.
The five-year survival rates of mucinous carcinoma (53.3%) and the group 25%<MC<50% (48.9%) after curative resection of the advanced carcinoma were relatively lower than that of differentiated type (68.2%).
The five-year survival rate (75.2%) in MC_??_25% group was almost equivalent to that of differentiated type.
As to mode of recurrenca, local or peritoneal recurrence was predominantly noted in mucinous carcinomas and 25%<MC<50% carcinomas.
It is throught that mucinous carcinomas tend to invade locally, and the same characteristic may be observed for colorecal carcinomas with mucinous component at moderate quantity.