A CASE REPORT OF ADENOSQUAMOUS CELL CARCINOMA OF THE GALLBLADDER

Abstract

Adenosquamous cell carcinoma that of is a relatively rare histological type of the gallbladder neoplasms is reported.
A 60-year-old woman visited another hospital because of epigastralgia, and was found to have a gallbladder mass with gallstone by ultrasonography, computed tomography and endoscopic retrograde cholangiography. The patient was seferred to the hospital with a suspicion of carcinoma of the gallbladder. On admission, there were a 4.0×2.5cm papillary lesion in the neck and a 2.0×1.5cm solid protuberant lesion in the body of gallbladder. Cholecystectomy, choledochotomy and partial resection of the liver (S1, S4a, S5) were performed, with reconstruction of choledochojejunostomy by Roux-en Y method. Histologically, The papillary lesion was well differetiated adenocarcinoma and the protuberant lesion well differentiated squamous cell carcinoma. The squamous metaplasia revealed basal portion of adenocarcinoma, and the invasion of the squamous cell carcinoma was deeper than that of the adenocarcinoma.
It was etiologically suggested that adenosquamous cell carcinoma might be caused by squamous metaplasia of adenocarcinoma in the gallbladder.