Abstract
A case of nonfunctioning adrenocortical carcinoma which is extremely rare is reported. A 45-year-old woman was admitted to the hospital because of gradually intensitying left hypochondralgia in a month and high fever. Abdominal ultrasonography showed a retroperitoneal mass about 10 cm in size. Adrenal origin was suspected strongly by angiography, but hormonal activities were in normal ranges, both adrenocortically and adrenomedullary. With diagnosis of non-functioning adrenocortical tumor, the tumor and left kidney were resected en-bloc, because direct invasion of the tumor to the left kidney was suspected. Adrenal dysfunction was not observed through out of the operation. In histopathological examination, it was diagnosed as adrenocortical carcinoma based on 1-2 mitotic figures per 10 high-power fields, considerable proportion of cells with eosinophilic cytoplasm, and tumor necrosis. The patient is scheduled to be given chemotherapy with low dose of CDDP+5-FU after the operation in the outpatient clinic, for preventing distant hematogenic metastasis that is common for the disease.
