2000 Volume 61 Issue 4 Pages 867-872
With respect to the immunohistochemical expression of TS, 18 cases of triple cancers were studied and all included gastric cancer. Of the gastric cancers, 3 were synchronous and the others were metachronous against 1 or 2 other cancers. The histological stages of gastric cancer ranged from stage I to IV, and included 9, 5, 2 and 2 cases in the ascending order of stage, respectively.
Overall expression of TS was 38.9% in gastric cancers. Chronologically, the rates were 12.5%, 37.5% and 50.0% in preceded, simultaneous and followed gastric cancers, respectively. TS was detectable in 76.0% of other cancers examined, of which colorectal cancer composed one third. Among 10 cases in which TS was examined in each triple cancer site, 2 had 3 cancers with TS(+), 5 had 2 cancers with TS(+) and 3 had 1 cancer with TS(+) and none had TS(-) in all. Prognosis was poorer for the group with positive TS in more than 2 cancer sites than in less TS positivity.
Therefore, it was considered that the prognosis of the triple cancer patients could be more predicted by combining TS positivity of each cancer.