DECREASE OF BONE MINERAL DENSITY AFTER GASTRECTOMY, AND THE EFFECT OF MENATETRENONE

Abstract

Using the quantitative computed tomography (QCT) technique, we investigated the vertebral trabecular bone mineral density of 24 subjects with gastric cancer who had undergone a gastrectomy 6 years ago previously. The purpose of this clinical study was to create a guide to therapy for osteoporosis after gastrectomy. QCT values 6 years after surgery had decreased to 108.00±83.38mg/cm³ from 140.52±63.87mg/cm³. The rate by contrast with non-operated age-group standard values 6 years after surgery (119.60±86.46%) was also significantly lower than during the perioperative period (139.64±55.11%). 15 male subjects including 5 who were taking alfacalcidol for 3 year, made a similar reduction. The QCT values in 9 male patients who were taking menatetrenone increased to 97.35±77.59mg/cm³ from 89.89±69.63mg/cm³ after medication, accompanied by the reduction of urine pyridinolin and urine deoxypyridinolin concentrations. Therefore, the possibility that menatetrenone is effective for osteoporosis after gastrectomy is suggested.