ADENOSQUAMOUS CARCINOMA OF THE GALLBLADDER WITH A HIGH LEVEL OF ALPHA-FETOPROTEIN (AFP)-A CASE REPORT-

Abstract

This paper presents a case of gallbladder cancer with a high level of alpha-fetoprotein (AFP). A 69-year-old man was admitted because of a pain below the right costal margin. Based on various examinations a diagnosis gallbladder cancer was determined. Extended resection of the gallbladder was carried out. Histopathologically, the gallbladder tumor was adenosquamous carcinoma, and adenocarcinoma was present in lymph node metastasis. Immunohistochemically, the carcinoma cells showed positive staining for AFP in only the lymph node metastasis. After operation, the level of AFP converted to negative. These findings suggest that gallbladder carcinoma cells produce AFP.