VALIDITY OF 2 HOUR CONTINUOUS HEPATIC ARTERIAL INFUSION CHEMOTHERAPY WITH LOW DOSE OF 5-FU FOR UNRESECTABLE LIVER METASTASES FROM COLORECTAL CANCER

Abstract

The significance of hepatic arterial infusion chemotherapy (HAI) for unresectable liver metastases from colorectal cancer (CRC) was evaluated. In patients with unresectale liver metastases from CRC whose original lesions were resected at our department previously, 25 patients undergoing HAI with a reservoir were defined as HAI group and 14 patients without HAI as a control group. Those 25 patients received either of the following regimens; hepatic arterial infusion of 5-FU for 2 hours+MMC (MF group); hepatic arterial infusion of 5-FU for 2 hours (5-FU group); and 1 shot of 5-FU+epirubicin+ MMC (FAM group). The mean survival time of the 25 patients in the HAI group was 15.2 months. In the P-factor negative 21 cases at the beginning of HAI, that of HAI effective cases was 22.1 months, versus 13.3 months in non-effective cases. On the other hand, that of regimens were 20.2, 20.0, and 10.9 months in NIF, 5-FU. and FAM groups, respectively. By comparison of cumulative survival rates, HAI group, HAI effective cases, MF group, and 5-FU group showed significant improvement in prognosis. In conclusion, 2 hour continuous HAI with low-dose of 5-FU for unresectable liver metastases from CRC may be helpful for improvement of prognosis.