A CASE OF DEEP VENOUS THROMBOSIS COMPLICATED WITH PULMONARY EMBOLISM CAUSED BY PROTEIN S DEFICIENCY

Abstract

A 27-year-old woman was admitted to our hospital because of pain and swelling of unknown cause in the left lower extremity. She was diagnosed as having deep venous thrombosis complicated with pulmonary embolism on imaging methods. We inserted a temporary vena cava filter to prevent aggravation of pulmonary embolism with anticoagulant therapy. No complications occurred during insertion of the filter and it was removed 13 days after insertion. Thereafter no severe complications occurred and the patient was discharged very much improved. This is thought to be a case of deep venous thrombosis due to protein S deficiency. In this case there were no probable causes of deep venous thrombosis other than a significant decrease in protein S activity. Protein S deficiency caused abnormal coagulation might originate these pathologic conditions in this case. In the treatment of young women of childbearing age, we must carefully indicate a temporary vena cava filter and select the type of the filter. Further we must follow them for a long time considering the time of withdrawing anticoagulation therapy and establish contact with their gynecologists closely.