Abstract
We investigated serum soluble CD44 standard (sCD44std), variant 6 (sCD44v6) and variant 8-10 (sCD44v8-10) levels from 40 patients with breast cancer before surgery. No significant relationship was detected between sCD44std concentrations and established pathological parameters. Conversely, elevated levels of sCD44v6 were found in the patients with tumor size larger than 2.0cm, positive node, and negative estrogen and progesterone receptors in comparison to healthy controls (p<0.05; respectively). Furthermore, elevated levels of sCD44v8-10 were found in the patients with tumor size larger than 2.0cm, positive node, and positive estrogen and/or progesterone receptor in comparison to healthy controls (p<0.05; respectively). Our results indicated that sCD44v6 and sCD44v8-10 might be indicators of tumor status in breast cancer patients preoperatively.
