Abstract
A 50-year-old woman with a palpable bean shaped mass in the upper outer quadrant of the left breast since May 2001 underwent excisinal biopsy, and solid-tubular carcinoma with scirrosum pattern was histopathologically diagnosed. The patient underwent quadrantectomy with axillary lymph node dissection 2 weeks after the biopsy. This case was in stage I (T1N0M0). She was given 5'DFUR (600mg, po) and local radiotherapy (30Gray) to the residual left breast, though no remnant cancer cell or lymph node metastasis was present. In January 2002, the patient with a 12-year history of bronchial asthma had attacks of athma, and was admitted to the hospital for evaluation of mononeuritis multiplex with paralysis of the lower extremities in April 2002. The patient was diagnosed as having Churg-Strauss Syndrome (CSS) because she had hypereosinophilia, hyper γ-globulinemia, and positive responses to rheumatoid factor and anti-nuclear antibodies. Steroid therapy for about one year led to dramatic improvement in the symptoms and laboratory findings, but in April, 2003 she was found to have recurrence with multiple liver matastases. She has been treated with chemotherapy. No report on CSS with liver matastases of breast cancer has been seen in the literature. Since CSS occurred after surgery for breast cancer followed by liver matastases after improvement of CSS with steroid therapy for a short time in this case, it was etiologically considered that immunological abnormality in autoimmune disease might be related to carcinogenesis.
