A CASE OF SOLITARY SPLENIC METASTASIS FROM OVARIAN CANCER WHICH RECURRED AFTER CHEMOTHERAPY

Abstract

We reported a case of solitary splenic metastasis that recurred after chemotherapy from ovarian cancer, together with a review of 14 of our own metastatic cases through November 2005.
A 70-year-old woman underwent performed hysterectomy, adnexectomy and partial omentectomy with intraperitoneal chemotherapy (IP) by CDDP for a left ovarian cancer in July 2002. Although a splenic metastasis and dissemination appeared on preoperative CT, they disappeared after postoperative chemotherapy (Paclitaxel+Carboplatin: TJ therapy). A solitary splenic metastasis was detected in September 2003. Splenectomy was pertormed because of the gradual increase of the tumor size in January 2005. Our chemosensitivity test for the metastatic splenic tumor revealed, no chemosensitivity to Paclitaxel. We suggest that Paclitaxel-resistant metastatic cells had regrown in this case, in spite of the completely controlled dissemination by IP and TJ therapy.