1969 Volume 10 Issue 3 Pages 465-469
The clinical course of a case of early diagnosed chronic myeloid leukemia was reported. The patient was a 41-year-old male, who had been working as X-ray technician for 15 years.
In 1963, his leukocyte count was normal. On July, 1966, Slight leukocytosis was accidentally found although he had neither complaints nor clinical signs at that time. Bone marrow aspiration and chromosomal analysis were carried out on September, 1966 and the diagnosis of CML was established by confirming Ph1 chromosome. Clinical manifestations of the disease (marked leukocytosis, anemia, splenomegaly etc.) became completed on March, 1968. Assuming that the onset was between 1963 and 1966, asymptomatic period of this case was roughly estimated 3.5 years.
Ferrokinetic studies revealed that the bone marrow erythropoietic activity was normal in 1966, but the extramedullary erythropoietic activity overwhelmed the bone marrow in 1966.
From March, 1968, 2 mg of busulfan were administered daily and the remission was successfully induced 3 months later.
