Abstract
A 28-year-old female was seen at Kyoto Univercity Hospital on Oct. 13, 1967, with a chief complaint of swelling of the generalized lymph nodes. A diagnosis of chronic myelocytic leukemia (CML) was made from the peripheral and bone marrow smears, a low score of leukocyte alkaline phosphatase and a positive Philadelphia chromosome (Ph1). Biopsy of the lymph nodes revealed leukemic infiltration with immature cells of the myeloid series. (myeloblastoma) On April 1968, leukemic hiatus in the bone marrow smears, a high score of leukocyte alkaline phosphatase and Ph1 with hyperdiploidy of the chromosome were recognized, by which a diagnosis of the blastic crisis was made. The lymph nodes grew larger in size and radiation and chemotherapy were performed without effect.
It was discussed that the marked lymph node enlargement was a poor prognostic sign appearing in the course of CML before blastic crisis.
