Abstract
In 14 children with leukemia, two patients were observed to have meningeal involvement in the past four years from 1966 through 1969.
One of them was treated with intrathecal administration of Methotrexate to induce complete relief. Meningeal involvement of leukemia was increased in the course of prolonged survival of patients under reasonable therapy, being invited at their remissional as well as aggravative conditions. This complication has seemingly increased recently and caused various neurologic signs or symptoms, of which. the most common signs were nausea, vomiting, headache and convulsion through increased cerebrospinal fluid pressure.
