1972 Volume 13 Issue 5 Pages 820-826
Procarbazine (Natulan) was administered to four patients with malignant lymphoma (2 cases with Hodgkin's disease and 2 cases with reticulum cell sarcoma) with combination of radiation, alkylating agents, Vinca alkaloids, Bleomycin or prednisolone. Significant responses were observed in two patients with Hodgkin's disease and in one of two cases with reticulum cell sarcoma. In a patient with Hodgkin's disease, who had been previously treated with radiation, Vinca alkaloids and alkylating agent, combination of procarbazine with radiation and Vinblastin was effective to induce remission again. It was suggested that procarbazine had no cross-resistance with these agents.
As side effects of procarbazine, pancytopenia was noted in all cases, but myelosuppression was gradually improved after cessation of administration. Significant toxic effects to the liver and kidney were not observed.
Combination of procarbazine with radiation or other anti-tumorous agents seems to be effective for the management of advanced cases with malignant lymphoma.
