Abstract
1. Effects of hydroxyethyl starch on blood coagulation and fibrinolysis were compared to those of dextrans.
The average molecular weight of hyproxyethyl starch was in the range from 30,000 to 40,000, and the degree of substitution was 0.55. The average molecular weights of two different types of dextrans used in this investigation were 40,000 and 70,000, respectively.
2. In vitro experiments revealed that the addition of hydroxyethyl starch or dextran to plasma resulted in accerelation of thrombin time, while there were no significant changes in partial thromboplastin time, prothrombin time, euglobulin lysis time and caseinolytic activity of plasma activated by streptokinase.
