Abstract
1. Hydroxyethyl starch was applied to seventeen patients as the blood substitute and examined its effects on blood coagulation and fibrinolysis.
2. 6% solution of hydroxyethyl starch in Ringer's solution with lactate was given ten patients intravenously at the dosis of 12.5ml per kg of body weight over a period of 1 hour.
The most striking effect of this substance was marked accerelation of thrombin time. Slight reduction in platelet count and fibrinogen titre was observed as well as slight prolongation of bleeding and prothrombin times, probably due to dilution effect of blood, though partial thromboplastin time showed no appreciable change. These effects lasted at least for 1 hour. Transient shortering of euglobulin lysis time was observed immediately after the infusion, but no adverse effect was seen in these patients given hydroxyethyl starch.
3. As the control, seven patients was infused Ringer's solution with lactate at the dosis of 12.5ml per kg of body weight over a period of 1 hour.
There were no significant changes in platelet count, partial thromboplastin, prothrombin and thrombin times as well as fibrinogen titre throughout the experiment. Euglobulin lysis time shortened transiently following the administration of Ringer's solution with lactate.
