Abstract
The important functions of the neutrophils are phagocytic and bacteriocidal activities, and these were studied on the relationship with neutrophil alkaline phosphatase (NAP) activity in various diseases, especially in CML.
Ink-phagocytosis was regarded to represent phagocytic and nitroBT (NBT) dye test, bacteriocidal activity.
Azo dye method was applied in NAP, test tube method phagocytosis and Park's modified method in NBT dye test, and those positive rate and score were counted.
These results were as follows.
Generally, in infectious diseases high values of these test were gained, but CML gave low values. (One case of atypical CML with high NAP activity gave low phagocytic and bacteriocidal activities, too.)
The results of our procedures suggested that though morphologically neutrophils of CML looked like matured cells, these functions were decreased.
