Abstract
A case of bleeding tendency attributed to unusual platelet dysfunetion was described. The retention of platelets in glass bead column was markedly decreased. The in vivo adhesiveness of platelets and platelet factor-3 availability were also decreased. Collagen—induced platelet aggregation and epinephrine-induced aggregation were markedly impaired, while ADP-induced aggregation was less defective.
The amount of platelet ADP was remarkably diminished, accompanied by slightly decreased ATP level. The release of ADP from platelets after collagen-induced aggregation was not observed. The labeling pattern of platelets by incubating them with adenine-8-14C was almost normal. However, a retarded metabolism of labeled ATP during collagen-induced aggregation was found. From these findings, a new platelet abnormality attributed to the defective adenine nucleotide metabolism, that is, “storage pool disease” was highly suspected.
