1974 Volume 15 Issue 9 Pages 1042-1048
A congenital factor VII deficiency is relatively rare disease and up to now, only 15 cases (11 families) have been reported in Japan. The present report concerns a female case of congenital factor VII deficiency, diagnosed at the age of 59. On admission, the physical examination revealed no abnormalities except for pyorrhea with continuous gum bleeding. She had often suffered from epistaxis, macrohematuria and petechiae with bruise since 10 years old. She had delivered 4 normal children without unusual bleeding. There was no history of hemorrhagic tendency in her family. Coagulation data showed the characteristic findings for pure factor VII deficiency (2% of normal) with vascular fragility. Liver function chemistries were within normal limit. The prolonged one stage prothrombin time was not shortened either by adding the prove congenital factor VII deficiency plasma or by the Vitamin K administration per os. The administration of Konyne-Cutter before dental extractions was effective for hemostasis.
