1974 Volume 15 Issue 9 Pages 1055-1062
This thirty-eight-year-old male was first seen on 26 December, 1972, with the chief complaint of muscle weakness. On admission papules were noted on the whole body. Lymph node swelling was seen at the both inguinal regions. Spleen was felt three fingerbreadths. Proximal type muscle atrophy, weakness and hyporeflexia were remarkable. No pathological reflexes were demonstrated.
Blood examination revealed hemoglobin 16.7 Gm./100 ml., red blood cells 5,630,000 per cu. mm., white blood cells 38,000 per cu. mm. with 49 per cent of lymphosarcoma cells, and platelet 196,000 per cu. mm. A sternal aspirate revealed slightly hypocellular marrow with 11 per cent of lymphosarcoma cells.
A biopsy specimen of the left inguinal lymph node showed a total disappearance of lymph follicles and a lymphosarcoma cell infiltration in the medullary cord. Biopsy findings of the M. triceps and M. peroneus revealed an extensive infiltration of the lymphosarcoma cells into the muscle tissue and a remarkable myogenic and partially neurogenic atrophy of the muscle fibers. During the hospital course the patient showed a meningeal lymphosarcomatosis, hypercalcemia and other complicated findings.
The patients died of cerebral hemorrhage on March 21, 1973. An extensive infiltration of the lymphosarcoma cells to the skeletal muscles was noted on autopsy.
