Hepatitis-Aplastic Anemia Syndrome

after the administration of chloramphenicol

Abstract

It is not so uncommon that aplastic anemia is induced by chloramphenicol. As regards aplastic anemia occured after hepatitis, however, only sixty cases have been reported, up to the present. This complex is called “the syndrome of hepatitis and aplastic anemis” by Rubin. Hodgikinson has recently documented the cases in which firstly hepatitis, secondary aplstic anemia are caused after the administration of chloramphenicol as the name of “Chloramphenicol—hepatitis—aplastic anemia syndrome”.
Our patient, thirty two years old, a house-wife was administrated 42 grams of chloramphenicol during the period of one month and suffered from hepatitis with marked jaundice four weeks later. In spite of recovering of liver function, she died of aplastic anemia.
Discussion of this paper are described about context of above three factors as follows; chloramphenicol and liver damage, hepatitis and aplastic anemia, and involvement of bone marrow and chloramphenicol.
Moreover the relationship between “Sinocapillaropathy of bone marrow” and each above mentioned three factors is discussed.