Abstract
A 48-year-old woman who had primary macroglobulinemia with acute clinical course was reported. She was admitted because of drug-induced hepatitis in Oct. 1971, with chief complaints of jaundice and general rash developed during treatment for common cold, and the recovery was satisfactory. During the four-months' hospital days, none of laboratory findings was suggestive of macroglobulinemia. Six months after discharge she again entered our hospital due to high fever, hematuria and palpitation. Serological findings revealed monoclonal gammapathy with an increase of IgM (3880 mg/dl). Hematological data showed pancytopenia and appearance of lymphoblastoid cells in peripheral blood and sternal bone marrow. She died on the eighth hospital day.
This case with acute clinical course seems to be unusual because most cases of primary macroglobulinemia are chronic.
