Abstract
In this investigation, we present a case of 24-year-old man with disseminated eosinophilic collagen disease. (Hereinafter we call it DECD.)
In January, 1971, he noticed frequent onsets of diarrhea, containing mucus and blood. In December, 1972, complaining of fever and pain of bilateral knee joints with swelling, he was admitted to our hospital for medical evaluation.
On physical examination, hepatosplenomegaly and lymphadenopathy were noted. The WBC count was 15,900 mm3 with 65.5% mature eosinophils. Bone marrow aspiration showed 64.3% eosinophils, but no increase of immature cell or blast cell were recognized. The ESR was 112mm/h. He had hypoproteinemia, liverdisfunction, and immunological abnormalities. Stool tests for ova and parasites were negative. Skin tests for allergens were also negative except for cotton. Eosinophils with mature cell were infiltrated on biopsy of cervical lymph-node. The structure of lymph-node was normal and there was no malignancy. His barium enema remarkably suggested a complication of ulcerative colitis.
The patient brilliantly responded to corticosteroid. The consultation and medical examination to him have been regularly followed up for two years by our clinic.
DECD is so closely akin to eosinophilic leukemia and some allergic or autoimmune diseases with eosinophilia that it is extremely difficult to make difference between them.
On the above matter, we had thoroughly discussed and issued him in DECD.
