Abstract
Both T- and B-lymphocytes in circulating peripheral blood and in bone marrow aspiration as well as the responsiveness in vitro to PHA-P and pokeweed mitogen were studied in the patients with hypoplastic anemia.
The numbers of circulating lymphocytes and T- and B-lymphocytes decreased in proportion to the severity of hypoplastic anemia while the null cell had increased. Significantly suppressed responsiveness to PHA-P in vitro was observed in the circulating lymphocytes and in the bone marrow lymphocytes.
On the contrary soloculture cpm increased in the bone marrow lymphocytes than in the circulating lymphocytes, and the responsiveness to pokeweed mitogen remained in the normal range in the circulating lymphocytes and suppressed in the bone marrow lymphocytes.
Effectively splenectomized cases showed an increased T- and B-lymphocytes in the circulating lymphocytes.
