1978 Volume 19 Issue 11 Pages 1519-1522
We have recently established a leukemic T-cell line (TALL-1) in permanent culture from the bone marrow of a patient in terminal leukemic stage of T-cell lymphosarcoma. Intraperitoneal implantation of 1.8∼2.9×107 TALL-1 cells gave rise to invasivetumors in all newborn Syrian hamsters treated with rabbit anti-hamster thymocyte serum after 26∼41 days. TALL-1 cells infiltrated various organs; involvement of the parathymic lymph nodes, liver, gallbladder, brain, meninges and uvea was the characteristic feature. Thus, this in vivo system would be useful for investigators concerned with studies on the characteristics and chemosensitivity of human T-cell leukemia-lymphoma. It is of interest to note that the donor had widespread leukemic involvement including the meninges and eyes during his clinical course.
