Second Syngeneic Bone Marrow Transplantation in a Case of Erythroleukemia

Abstract

A 16-year-old boy with recurrent erythroleukemia in blastic phase was successfully retransplanted with the identical twin marrow. He was found to have erythroleukemia in April 1975. Eight months remission was obtained with the first transplant from his identical twin donor after an intensive combination chemotherapy and active immunotherapy as a maintenance. Cyclophosphamide and total body irradiation were used for the conditioning of the second transplant. The donor was immunized with key hole limpet hemocyanin (KLH) and subsequent sensitization of the recipient gave an evidence for graft acceptance. The recipient died from an accident on the day 125 in a remission state.