Effects of a small dose of fluoxymesterone on aplastic anemia

Abstract

Effects of a small dose of fluoxymesterone, 30 mg/day in man and 10 mg/day in woman, were examined on patients with aplastic anemia. The attending physicians belonging to Fluoxymesterone Study Group treated 46 patients, 19 males and 27 females, suffering from acquired aplastic anemia. The RBC, hemoglobin, hematocrit, reticulocyte, mean corpuscular constants, WBC, differential counts and platelet levels were used as hematopoietic parameters of the success of therapy, and GOT, GPT, virilization and glucosuria were checked to monitor the development of any side-effects.
Following to Professor MIWA's criteria, remission was seen in 47.4% of males and 70.4% of females after three months, and this rose to 83.3% in males and 100% in females after nine months.
After both three and twelve months of administration, about 16.7∼41.7% of the patients showed abnormal GOT and GPT levels, while about 5.3∼33.3% showed signs of virilization and glucosuria were observed in 4.4%.
It may be suggested that a small dose of fluoxymesterone is effective on aplastic anemia and induces a less side-effect, especially in female, in comparison to a large dose of it.