1980 Volume 21 Issue 1 Pages 1-9
Cytogenetic study on bone marrow cells of 37 patients with acute non-lymphocytic leukemia was performed at the initial examination of the patients using banding technique.
Acute myeloblastic leukemia (AML) was diagnosed in 19 patients, acute promyelocytic leukemia (APL) in 4, acute monocytic leukemia (AMoL) in 1, atypical leukemia (Aty-L) in 10, and erythroleukemia (EL) in 3.
Chromosomal abnormalities were observed in 11 patients of AML, none of APL, 1 of AMoL, 4 of Aty-L, and 3 of EL, totalling 19 patients.
Four cases of AML showed (8; 21) translocation and hematological findings in common. The median survival times were 7.6 months for patients with normal karyotype only, 3.2 months for patients with both abnormal and normal karyotypes, and 4.0 months for patients with abnormal metaphase only. However, there was no statistically significant difference among these three groups.
