Abstract
Granulopoietic and erythropoietic progenitor cells (CFC and CFUe) in bone marrow from childen with hematological disorders were assayed using methylcellulose clonal cell culture.
Marked reduction of CFC and/or CFUe in bone marrow were observed in the following disorders: onset or relapse in acute leukemia, smoldering acute leukemia, preleukemia, exacerbation in aplastic anemia, pure red cell anemia, congenital neutropenia, acute phase in agranulocytosis or transient pancytopenia, malignant histiocytosis, neuroblastoma with metastasis, and children received intensive chemotherapy or irradiation.
Possible mechaisms of CFC and/or CFUe reductions in each cases are discussed and a etiological classification of marrow stem cell reduction is attempted.
