Abstract
Several factors were studied which might affect the prognosis of 55 patients with ANLL and ALL. Amoung our results, we found that the remission rate of patients over 50 years old was 36.0%, as compared to a remission rate of 85.0% for the patients under 50, suggesting that a patient's age seems to most strongly affect remission. Age also affected the length of survival, which was only 5.9 months for the over-50 group, compared to 18.8 months for younger patients. In ANLL, the remission rate was apparently higher for patients with low WBC (<3×104/ul) and with low peripheral blast cell counts (<2×104/ul) than for those with high WBC and high blast cell counts. In cases which showed low LAP activity (<190), the remission rate was significantly higher (70.0%) than those with high LAP activity (29.4%) (p>0.05). The median survival time also was longer in the low LAP activity group (p<0.005). The remission rate was higher and survival longer in patients in whom no chromosome abnormality was seen. Thus, our results suggest that an age under 50, a low peripheral leukocyte count, low LAP activity and an absence of chromosomal abnomalities are the factors pointing to the most favorable prognosis in an acute leukemic patient.
