Abstract
Case 1: 55 years old female. Ig A-K type myeloma. Two courses of MP-therapy (Melphalan 10mg/d×7d and Prednisolone 30mg/d×7d) succeeded to give rise a hematological remission, although she was not able to walk owing to pain due to pseudoarthrosis of her hip joints. Endoprosthesis of the right femoral head made possible to walk by herself. In spite of repeated MP-therapies, a hematological relapse with extramedullary myeloma (EM) occured. Two courses of AAAP-therapy—ACNU 50mg/d IV (drip over 4 hrs), Adriamycin 20mg/d IV (push), Methotrexate 25mg/d IV (push), and Prednisolone 60mg/d IV (push): once a two or three weeks—was effective so that hematological remission and diminution of EM were observed.
Case 2: 64 years old female. Bence Jones L type myeloma.
A hematological remission was seen after one course of MP-therapy, however she was unable to walk because of pain due to pseudoarthrosis of the left hip joint. The endoprosthesis succeeded to enable her to walk on crutches. After that, a hematological relapse with EM occured in spite of repeated MP-therapies. Since the radiation with 60Co 6,600 rads failed to give any beneficial result, it was observed that AAAP-therapy resulted in a complete diminution of EM as well as a hematological remission.
Thus, AAAP-therapy was disclosed one of the excellent chemotherapies for myeloma in relapse.
And we considered that it would be worth doing endoprosthesis of the femoral head to enjoy a normal day of activity in a patient of myeloma with pain due to pseudoarthrosis of the hip joints.
