Abstract
57 y. o. male
Patient was quite well until he was administered to a hospital because of a trafic accident. During the hospital stay he was found to have the hepatosplenomegaly and diagnosed as Banti syndrome. The pathohistological examination on his exstirpated spleen revealed the presence of depositis of amyloid. He had the thyroid and adrenocortical hypofunction due to pituitary hypofunction. He had the λ type macroglobulinemia and the Bence-Jones proteinuria. The amyloid protein was stained specifically by FITC labeled anti-λ light chain antibodies. A marked decrease of IgG and IgA Sm-Ig bearing B cells and a marked increase of IgM Sm-Ig bearing B cells were demonstrated. A marked decrease of and Tγ cells and marked increase of B cells were demonstrated. The in vitro IgG and IgA production of B cells by the stimulation of PWM was markedly decreased but the IgM production was within normal limits. When patient's T cells and normal allogeneic B cells were mixed lymphocytes cultured and then B cells were stimulated by PWM, their production of IgG, IgA and IgM was markedly reduced, suggesting the increase of suppressor T cells in the patient. Patient's B cells were resistant to he regulation of their differentiation to IgM producing cells by normal activated suppressor T cells.
