Abstract
Thirtyfive-year-old female was admitted complaining of palpitation, myalgia, arthralgia and left hypochondralgia. The diagnosis was considered to be chronic myelocytic leukaemia (CML) presenting in blastic transformation (BT) from the findings of hepatosplenomegaly, anaemia, leukocytosis, myelogram and positive Ph1 chromosome. The patient was treated with V-P therapy and partial remission was achieved. After 40 days in partial remission, blasts in the peripheral blood and bone marrow increased rapidly. We continued V-P therapy but no effect was achieved. Then we tested a combination of V-P therapy, ACNU, and cytosine arabinoside. But this combination was not effective. The patient died 10 days after administration of ACNU due to progressive respiratory insufficiency. At autopsy, pathologic diagnosis was done as AML with secondary pulmonary fibrosis.
