Abstract
A clinical study of coagulation-fibrinolytic abnormalities in 96 patients with primary lung cancer, 12 patients with metastatic lung cancer and 27 patients with leukemia was undertaken.
Patients with lung cancer in advanced stages were found to be in the hypercoagulable state, which consisted of intravascular coagulation and secondary fibrinolysis. It was noted that the measurements of fibrinogen, FPA, ATIII and FDP were useful and important to analyze the pathophysiology.
It was suggested that DIC was the final condition of intravascular coagulation and secondary fibrinolysis exhausted of various factors, and that DIC might be considered to be a presenting pattern of the hypercoagulable state in a broad sense.
Heparin therapy was considered to be the most important way against the hypercoagulable state in malignancy. Our data indicates that the beneficial clinical effects of heparin can be obtained by keeping the heparin level 0.73±0.51 IU/ml in blood. And it is also necessary to measure fibrinogen, FPA, ATIII, FDP and PF4.
