Abstract
Two cases of purpura hyperglobulinemica were observed. The first case, 30-year-old female, presented purpura on the both lower extremities and diffuse swelling of the left parotid gland with normal salivary excretion. The second case, 27-year-old female, presented purpura on both legs after longtime standing. Both cases showed accelerated erythrocyte sedimentation rate, polyclonal hypergammaglobulinemia (31.4% and 36.4%), positive RA test and positive anti-platelet antibody by indirect Coombs' consumption test.
Besides, the second case revealed positive anti-nuclear factor (speckled pattern) and decrease of values of C4 and C3C, however, since renal biopsy disclosed no deposit of immunoglobulin nor complement, the diagnosis as SLE was excluded. Administration of prednisolone brought good clinical effects and reappearance of purpura was hardly seen even after provocation in both cases.
It would be suggested that purpura hyperglobulinemica is a prodromal or partial symptom of collagen disease, therefore, the careful follow-up study should be needed.
