本態性血小板血症の診断4年4カ月後に急性骨髄性白血病に移行した1例

飯塚 芳一; 馬場 真澄; 森本 幸治; 志田 光正; 和泉 徹; 早川 佳夫; 団 茂樹; 堀越 昶; 竹内 仁; 伊藤 武善; 武尾 宏; 雨宮 洋一; 沢田 海彦; 東海 俊英; 大島 年照; 天木 一太

doi:10.11406/rinketsu.22.46

A Case of Essential Thrombocythemia Transformed to Acute Myeloblastic Leukemia

Yoshikazu IIZUKA, Masumi BABA, Kohji MORIMOTO, Mitsumasa SHIDA, Toru IZUMI, Yoshio HAYAKAWA, Shigeki DAN, Akira HORIKOSHI, Jin TAKEUCHI, Takeyoshi ITOH, Hiroshi TAKEO, Yoichi AMEMIYA, Umihiko SAWADA, Toshihide TOHKAI, Toshiteru OHSHIMA, Ichita AMAKI

Author information

Yoshikazu IIZUKA
The First Department of Internal Medicine, Nihon University, School of Medicine
Masumi BABA
The First Department of Internal Medicine, Nihon University, School of Medicine
Kohji MORIMOTO
The First Department of Internal Medicine, Nihon University, School of Medicine
Mitsumasa SHIDA
The First Department of Internal Medicine, Nihon University, School of Medicine
Toru IZUMI
The First Department of Internal Medicine, Nihon University, School of Medicine
Yoshio HAYAKAWA
The First Department of Internal Medicine, Nihon University, School of Medicine
Shigeki DAN
The First Department of Internal Medicine, Nihon University, School of Medicine
Akira HORIKOSHI
The First Department of Internal Medicine, Nihon University, School of Medicine
Jin TAKEUCHI
The First Department of Internal Medicine, Nihon University, School of Medicine
Takeyoshi ITOH
The First Department of Internal Medicine, Nihon University, School of Medicine
Hiroshi TAKEO
The First Department of Internal Medicine, Nihon University, School of Medicine
Yoichi AMEMIYA
The First Department of Internal Medicine, Nihon University, School of Medicine
Umihiko SAWADA
The First Department of Internal Medicine, Nihon University, School of Medicine
Toshihide TOHKAI
The First Department of Internal Medicine, Nihon University, School of Medicine
Toshiteru OHSHIMA
The First Department of Internal Medicine, Nihon University, School of Medicine
Ichita AMAKI
The First Department of Internal Medicine, Nihon University, School of Medicine

Keywords: Essential thrombocythemia, Auer rods, Acute myeloblastic leukemia

JOURNAL RESTRICTED ACCESS

1981 Volume 22 Issue 1 Pages 46-53

DOI https://doi.org/10.11406/rinketsu.22.46

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Abstract

A 70 years old woman was admitted to the Nihon University Hospital in December 1974 because of general fatigue, loss of appetite, hepatomegaly and papules for 2 months. The platelet counts on admission was 3.2×10⁶/μl, the bone marrow aspiration and biopsy revealed marked increase in number of magakaryocytes. The diagnosis of essential thrombocythemia was made on the base of thrombokinetic studies.
Total 198mg of Busulfan was given to maintain platelet counts between 0.5 and 1.7×10⁶/μl.
In April 1979, the platlet counts decreased to 0.14×10⁶/μl, leukocyte counts was 35,200/μl, with 87.5% of blast cells. Bone marrow aspiration showed 71.8% of blast cells with Auer rods. Diangosis of acute myeloblastic leukemia was made. A complete remission was not achieved with various antileukemic agents. She died of intracranial bleeding in October 12, 1979. Our case and 7 case of blastic transformation from essential thrombocythemia in literature were discussed.

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