1981 Volume 22 Issue 10 Pages 1565-1571
The administration of cyclophosphamiade, melphalan, etc. to a 48-year-old woman who had IgG-K myeloma resulted in remission of the disease after 14 months. Subsequently, a serious orientational disorder occurred 6 months after the remission, followed by progressive dementia. Freqent attacks of spasm and serious clouding of consciousness occurred in the last stage of the disease. The patient died 6 years after the first consultation. Autopsy findings revealed the following: a decrease in brain weight (final wt., 920g); wide-ranging atrophy of and defects in the white matter of the cerebrum, especially, of the vertex and the occipital lobe; necrosis, demyelinization, and Alzheimer-II glia, mainly in the white matter of the vertex and the occipital lobe as histological findings. Some comments on this disease are also made on the basis of the related literature.
