Abstract
Two cases of so-called adult T cell malignancy were presented, one was diagnosed as Sézary syndrome and the other, as adult T cell leukemia. They showed, in common, lymphnode swelling, hepatomegaly, bone lesion associated with hypercalcemia, and exfoliative erythematous skin lesions, in which an infiltration of leukemic cells was found. One patient was born in Kyushu district and the other in Taiwan. Smears of peripheral blood showed convoluted lymphoblastic cells with T-cell markers. Adult T cell leukemia showed multiple cutaneous tumors, but Sezary syndrome did not. At present, it is quite natural that we put both, Sezary syndrome and adult T cell leukemia, into the same clinical category as adult pleomorphic type in T cell malignancy. Hypercalcemia seemed to be caused by bone infiltration, in Sezary syndrome, and a local humoral factor such as osteoclast activating factnr in adult T cell leukemia.
