Abstract
Eight (9.4%) of 85 patients with non-Hodgkin's lymphoma admitted in our hospital during the past ten years developed the meningeal involvement. These 8 patients had a diffuse histologic subtype. At the time of diagnosis of the meningeal involvement, other extranodal sites were already involved in five patients, and the most commonly involved extranodal site was bone marrow.
Local treatment with intrathecal chemotherapy and/or whole brain irradiation was effective, but systemic treatment with intensive combination chemotherapy was not effective. So the survival range after the developement of the meningeal involvement was very short, and six patients died within three months.
