Distinction Between Fibrinogen and Fibrin Degradation Products in Serum from Patients with DIC

Abstract

FDP (fibrin/fibrinogen degradation products) in serum from patients with DIC (disseminated intravascular coagulation) have been characterized using a method of immunoabsorption followed by SDS-polyacrylamide gel electrophoresis. In all five patients with DIC, fragment D-dimer, derived from cross-linked fibrin, as well as fibrinogen degradative fragments (X, Y, D) were detected. It appears that in DIC primary and secondary fibrinolysis may take place, and both anticoagulants and anti-fibrinolytic agents should be given.