Two Cases of Pre-B-Cell Leukemia in Childhood

Abstract

Two cases of Pre-B-cell leukemia in childhood were reported. Immunologic studies demostrated no rosette formation with SRBC at 37°C lack of surface immunoglobulins, and presence of cytoplasmic-IgM in the lymphoblast.
On electron microscopy, the lymphoblast had round nuclei, abundant free ribosomes, several strands of rough endoplasmic reticulum in the cytoplasm, and no microvilli on the surface.
Clinically, the patients easily entered to complete remission. However, the duration of first remission was somewhat short, being about one year. There was a tendency to repeat relapses.